ATHEROTHROMBOTIC Cardiovascular diseases (CVDs) such as myocardial infarction (MI) and stroke are multifactorial disorders with substantial heritable components. Genetic constitution may contribute to underlying risk factors such as hypertension, diabetes mellitus, and hypercholesterolemia and also may act through other, unidentified routes to alter susceptibility to CVDevents.
POSTMENOPAUSAL WOMEN WHO use hormone therapy are known to have a reduced incidence of fracture compared with women who do not. However, there is limited information on how long this protective effect persists after use ceases, how different types of hormones affect the risk of fracture, and how hormone therapy affects the risk of fracture of different bones.
The stress system orchestrates body and brain responses to the environment. This action exerted by the mediators of the stress system has two modes of operation. The immediate response mode driven by corticotropin-releasing hormone (CRH) organises via CRH-1 receptors the behavioural, sympathetic and hypothalamic-pituitary-adrenal (HPA) responses to a stressor.
THE PREVALENCE OF OBESITY HAS increased dramatically in the past decade in the United States and many other developed countries. Because obesity is associated with a significantly increased risk for type 2 diabetes, coronary heart disease, hypertension, numerous other major illnesses, and overall mortality from all causes, weight reduction is critical for the obese patient.